Anti-Smoking Drug's Adverse Effects

Smoking drug Champix linked to adverse psychiatric effects: Health Canada

Health Canada has issued a warning about adverse neuropsychiatric effects linked to Champix, a drug intended to help smokers butt out for good.

A number of patients taking Champix (varenicline tartrate) have experienced unusual feelings of agitation, depressed mood, hostility, changes in behaviour or impulsive or disturbing thoughts, such as ideas of self-harm or of harming others, Health Canada said Friday in an advisory.

The medication acts on sites in the brain affected by nicotine. The drug helps ease withdrawal symptoms and blocks the effects of nicotine if users resume smoking.

Champix, made by Pfizer Inc. and sold under the brand name Chantix in the United States, has been sold in Canada since April 2007. In the year following its approval, 226 Canadian cases of neuropsychiatric adverse events have been reported. In that period, more than 708,500 prescriptions for the drug have been filled across the country.

Health Canada issued the following guidelines to the public:

• Tell your doctor if you have experienced depression or other mental health problems before taking Champix, as these symptoms may worsen while taking the drug.
• Stop taking Champix and tell your doctor right away if you, your family or caregiver have noticed any of these symptoms, if you experienced these symptoms in a way that is not typical for you or if you have thoughts of self-harm or of harming others.
• Champix has not been studied in people with mental health problems, and therefore your doctor will be monitoring you closely for new or worsened emotional or behavioural problems while on the medication.

"Quitting smoking can also be associated with changes in mood and behaviour, with or without taking medication to help quit," said the federal department in its advisory. "A doctor or pharmacist should be consulted should these symptoms or those described above be experienced, since guidance has been provided to health-care professionals on how to use Champix in patients, including those patients who may also have mental health problems."

Health Canada, which published an article concerning Champix in the Canadian Adverse Reaction Newsletter in April, said any case of serious change in mood or behaviour or other serious or unexpected adverse reactions in patients receiving Champix should be reported.

Source:CBC.ca

Ease Fibromyalgia with Holistic Exercise Approach

Exercise eases fibromyalgia pain

Regular walks and stretching exercises can help ease the chronic, depressing pain of fibromyalgia, a mysterious ailment with no obvious cure, researchers said on Monday.

Striking more than 3 per cent of U.S. women and 0.5 per cent of men, the illness' primary symptoms are debilitating pain throughout the body -- often with sensitivity and stiffness focused in the joints. Other symptoms include sleep problems, fatigue and depression.

No single test can diagnose fibromyalgia, and sometimes patients are treated with behavioural therapy.

Pregablin, a drug that calms nerve cells, gained U.S. regulatory approval in June to treat the pain from fibromyalgia. It is sold as Lyrica by Pfizer Inc.

In a study of 207 women aged 18 to 75 diagnosed with fibromyalgia, researchers assigned one group to a twice-weekly aerobic and stretching program for 16 weeks. Another group added mild strength training, a third group attended a two-hour education course every two weeks, and a fourth combined all the approaches. The 135 women who completed the courses were reevaluated six months later.

"An appropriately structured exercise program that involves progressive walking and flexibility movements with or without strength training improves physical, emotional and social function," concluded study author Daniel Rooks of Brigham & Women's Hospital and Harvard Medical School, Boston.

Assessing their own well-being, the participants scored better in such categories as pain reduction, physical functioning and vitality after completing the courses. Those who both exercised and took the education course improved the most.

"The beneficial effect on physical function of exercise alone and in combination with education persisted at six months," Dr. Rooks said in the report published in the Archives of Internal Medicine.

Such findings should encourage people with aches and pains to exercise more, as they tend to be "even less active than the relatively sedentary general public," the report said.

Source: TheGlobeandMail.com