Anti-Smoking Drug's Adverse Effects

Smoking drug Champix linked to adverse psychiatric effects: Health Canada

Health Canada has issued a warning about adverse neuropsychiatric effects linked to Champix, a drug intended to help smokers butt out for good.

A number of patients taking Champix (varenicline tartrate) have experienced unusual feelings of agitation, depressed mood, hostility, changes in behaviour or impulsive or disturbing thoughts, such as ideas of self-harm or of harming others, Health Canada said Friday in an advisory.

The medication acts on sites in the brain affected by nicotine. The drug helps ease withdrawal symptoms and blocks the effects of nicotine if users resume smoking.

Champix, made by Pfizer Inc. and sold under the brand name Chantix in the United States, has been sold in Canada since April 2007. In the year following its approval, 226 Canadian cases of neuropsychiatric adverse events have been reported. In that period, more than 708,500 prescriptions for the drug have been filled across the country.

Health Canada issued the following guidelines to the public:

• Tell your doctor if you have experienced depression or other mental health problems before taking Champix, as these symptoms may worsen while taking the drug.
• Stop taking Champix and tell your doctor right away if you, your family or caregiver have noticed any of these symptoms, if you experienced these symptoms in a way that is not typical for you or if you have thoughts of self-harm or of harming others.
• Champix has not been studied in people with mental health problems, and therefore your doctor will be monitoring you closely for new or worsened emotional or behavioural problems while on the medication.

"Quitting smoking can also be associated with changes in mood and behaviour, with or without taking medication to help quit," said the federal department in its advisory. "A doctor or pharmacist should be consulted should these symptoms or those described above be experienced, since guidance has been provided to health-care professionals on how to use Champix in patients, including those patients who may also have mental health problems."

Health Canada, which published an article concerning Champix in the Canadian Adverse Reaction Newsletter in April, said any case of serious change in mood or behaviour or other serious or unexpected adverse reactions in patients receiving Champix should be reported.

Source:CBC.ca

Exercise Sequencing for Better Heart Benefits

Source: Women's Health March 3008

Supplement MisLabelling

Source: Women's Health April 2008

Car Smoking Ban - Ontario

Ontario bans smoking in cars with kids under 16

Ontario became the latest province to ban adults from smoking in cars where children are present Monday after a government-backed bill passed in the legislature with support from all parties.

The province already bans smoking in workplaces and public areas, such as bars and restaurants. The new ban will also protect kids under the age of 16 who are being exposed to dangerous levels of second-hand smoke, said Health Promotion Minister Margarett Best.

"This is about protection of our most vulnerable citizens — children who do not have a voice," Best told the legislature.

Premier Dalton McGuinty once dismissed a province-wide ban as a slippery slope that infringed too much on people's rights, but changed his tune in March and threw his government's support behind the private members' bill.

Offenders will also face much lighter fines than originally envisioned by Liberal backbencher David Orazietti, who championed the ban. Drivers and passengers who don't butt out in vehicles carrying children won't be fined more than $250 for each offence, rather than being penalized up to $1,000.

Nova Scotia and British Columbia have already outlawed the practice, which critics liken to child abuse. Prince Edward Island and New Brunswick are also considering a similar ban.

Police will be expected to enforce the law once it takes effect, but the province is counting on most people abiding by the law, said Best.

Ontario Provincial Police have said the ban won't make their job more onerous, as they are already inspecting for seatbelts and child car seats.

The province says kids are exposed to up to 27 times the toxins when they're in enclosed spaces like a car, which can worsen asthma and lead to other respiratory illnesses.

Mychoice.ca, a smokers' rights group financed in part by the tobacco industry, has raised concerns that the ban will eventually extend to private homes, but Mr. McGuinty said that's not under consideration

Source: GlobeandMail.ca

Shorter Effective Workout Routines Bring Gains

A shorter workout – but it will hurt

The question

Can I get fit by exercising just a few minutes a week?

The answer

Breathless claims about exercise regimens that produce near-instant results with minimal effort are generally the domain of late-night infomercials and their ilk.

So it may seem surprising that one of the hot topics at last month's American College of Sports Medicine annual meeting in Indianapolis was research on "high-intensity interval training" (HIT), suggesting that many of the benefits of traditional endurance training can be achieved with a few short bouts of intense exercise totalling as little as seven minutes a week.

The latest research on the topic, from a group at Hamilton's McMaster University, was just published in the online edition of the American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. It shows that that HIT improves the structure and function of key arteries that deliver blood to the muscles and heart, just like typical cardio training.

The McMaster group has produced a series of remarkable studies on HIT over the past few years, led by exercise physiologist Martin Gibala.

Their subjects cycled as hard as they could for 30 seconds, then rested for four minutes, and repeated four to six times. They did this short workout three times a week.

"The gains are quite substantial," Dr. Gibala says. When compared with control subjects who cycled continuously for up to an hour a day, five times a week, the HIT subjects showed similar gains in exercise capacity, muscle metabolism and cardiovascular fitness.

Similar studies by University of Guelph researcher Jason Talanian have found that interval training also increases the body's ability to burn fat, an effect that persists even during lower-intensity activities following the interval training.

The results are no surprise to elite cyclists, runners and swimmers, who have relied on interval training for decades to achieve peak performance. To break the four-minute mile in 1954, Roger Bannister famously relied on interval sessions of 10 60-second sprints separated by two minutes of rest, because his duties as a medical student on clinical rotation limited his training time to half an hour a day at lunch.

Such time constraints are the main reason Dr. Gibala advocates HIT, since studies consistently find that lack of time is the top reason that people don't manage to get the 30 to 60 minutes of daily exercise recommended by public health guidelines.

"We're not saying that it's a panacea that has all the benefits of [traditional] endurance training," he says. "But it's a way that people can get away with less."

High-intensity exercise is generally thought to carry some risks, so sedentary or older people should check with a doctor before trying HIT. Interestingly, though, University of British Columbia researcher Darren Warburton presented results in Indianapolis showing his work with cancer and heart disease patients, demonstrating that these higher-risk populations can also benefit safely from HIT.

There is a catch - the disclaimer at the end of the infomercial, if you will. To cram the benefits of an hour-long workout into a few short minutes, you also have to compress the effort you would have spent.

"That's the trade-off," Dr. Gibala says. "Going all out is uncomfortable. It hurts." But at least with this approach it's over quickly.

How to take a HIT

The guiding principle of HIT is that the shorter the workout, the higher the intensity you need to reap the benefits. "Basically," McMaster University's Martin Gibala says, "you need to get out of your comfort zone." Start by trying a HIT workout once or twice a week.

The Street-lighter: For a sedentary person who gets winded walking around the block, HIT can be as simple as walking more quickly than usual between two light poles. Then back off, and repeat after you have recovered.

The Bannister: Go hard for one minute, then recover (either

by slowing down or stopping completely) for one to two minutes. Repeat 10 times. This is a staple workout for a wide range of abilities, suitable for any

cardio activity.

The Timesaver: Dr. Gibala's protocol of 30 seconds of all-out cycling four to six times with four minutes rest is the shortest workout shown to be effective. But achieving the necessary intensity outside the lab is extremely challenging, so it's best suited to experts and those capable of extreme self-punishment.

All these workouts should be preceded by a gentle warm-up of at least five to 10 minutes.

Alex Hutchinson

Source: GlobeandMail.ca

Ill Effects of Pop

Source: Men's Health April 2008

Health Canada Advisory Against Ephedra Use

Health Canada is reminding consumers not to use products containing Ephedra or ephedrine, either alone or in combination with caffeine and other stimulants. These products may have serious, possibly fatal, adverse effects.